Computers Troublesome Spyware

I'm having some trouble deleting some spyware off my computer and i'm wondering can anyone help.

They main source of the problem is some spyware called Surf Sidekick. I've run Ad-Aware and Spybot to try and solve the problem, but to no avail. When i run Ad-Aware, i'm told in the result that this folder is spyware, but when i order it to delete it, i get a message telling me that it can't do it and will try to do so on the next reboot. However it never does and its always there. I've found the file on my hard drive but when i try to delete it i get a message telling me that there is a sharing violation and that it may be in use. To try and combat this i have tried starting my computer without my modem powered off so that there would be no connection for it to use, but i still get the same sharing violation error.

I haven't a clue what else to do and its getting really annouying not being able to do anything on the computer without all these ad's poping up for no reason, even when i'm not using a browser. Can anyone give me some help?

 

Try rebooting in Safe Mode and running your anti-spyware software- this should prevent it from starting up in the backgroud and giving you that "File may be in use" message. It doesn't have to have an active connection in order to be running, after all.

 

Oh, indeed. The best I've ever seen either perform had them both catch some 700 spywares each, on the same computer, in subsequent runs.

And, just in case you're not sure how to run Safe Mode:
http://www.bleepingcomputer.com/tutorials/tutorial61.html

 

None of the above have worked, i still can't seem to get rid of that file, its always in use even in safe mode. I'm totally out of ideas .